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Nucleosides and Nucleotides Volume 10, 1991 - Issue 1-3: Proceedings of the 9th International Round Table
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More Efficient Alkylating Oligonucleotide Derivatives for the Sequence Specific Chemical Modification of dsDNA

V. V. Vlassov Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk, 630090, USSR
,
A. A. Godovikov Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk, 630090, USSR
,
A. A. Gall Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk, 630090, USSR
,
E. M. Ivanova Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk, 630090, USSR
&
A. U. Semeryanova Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk, 630090, USSR
Pages 527-529 | Published online: 29 Aug 2007
 
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Abstract

Derivatives of (pT)16 bearing alkylating groups coupled to the 5′-terminal phosphate by the flexible linker alkylates the & DNA efficiently in vicinity of (A18)(T18) sequence.

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