Solid-Phase Synthesis of Oligodeoxyribonucleotide Analogues Containing 5, 6-Dihydroimidazo [1, 2-c] Pyrimidin-5-One as a Base Moiety

Abstract

The synthesis on a polyacrylamide resin of oligonucleotides containing 5,6-dihydroimidazo [1, 2-c] pyrimidin-5-one (X) as a base residue is described. Perliminary results on enzymatic hydrolysis of the modified octanucleotide d(TXAATTCA) (21), containing. the recognition sequence for the endonuclease -ECO RI where dG is replaced by dX (1), are reported.