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Nucleosides and Nucleotides Volume 10, 1991 - Issue 7
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Original Articles

Synthesis And Antiviral Evaluation Of 2′,3′-Secothymidine Analogs of ddT and AZT

Annie-Fransoise Maggio Laboratoire de Chimie Bio-Organique, UMR 112 Synthélabo-CNRS-USTL, Université II Sciences et Techniques du Languedoc, Place Eugène Bataillon, 34095, Montpellier-Cédex 5, France
,
Valerie Boyer Laboratoire de Chimie Bio-Organique, UMR 112 Synthélabo-CNRS-USTL, Université II Sciences et Techniques du Languedoc, Place Eugène Bataillon, 34095, Montpellier-Cédex 5, France
,
Anne-Marie Aubertin U. 74 de l'INSERM, Laboratoire de Virologie de la Faculté de Médecine, Université Louis-Pasteur, 3 rue Koeberlé, 67000, Strasbourg, France
,
Georges Obert U. 74 de l'INSERM, Laboratoire de Virologie de la Faculté de Médecine, Université Louis-Pasteur, 3 rue Koeberlé, 67000, Strasbourg, France
,
André Kirn U. 74 de l'INSERM, Laboratoire de Virologie de la Faculté de Médecine, Université Louis-Pasteur, 3 rue Koeberlé, 67000, Strasbourg, France
&
Jean-Louis Imbach Laboratoire de Chimie Bio-Organique, UMR 112 Synthélabo-CNRS-USTL, Université II Sciences et Techniques du Languedoc, Place Eugène Bataillon, 34095, Montpellier-Cédex 5, France
Pages 1431-1449 | Received 17 Jul 1990, Accepted 15 Feb 1991, Published online: 04 Oct 2006
 
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Abstract

2′,3′-Secothymidine derivatives related to AZT and ddT have been synthesized and evaluated for their activity against HIV-1 and various DNA and RNA viruses. These acyclic nucleosides exhibited no antiviral activities.

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