Coronary Vasoactivity of Novel N⁶-Substituted Adenosines

Shozo Kusachi Department of Internal Medicine, Box 19, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612

Robert D. Thompson Department of Internal Medicine, Box 19, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612

William J. Bugni Department of Internal Medicine, Box 19, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612

Nobuyuki Yamada Department of Internal Medicine, Box 19, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612

Ray A. Olsson Department of Internal Medicine, Box 19, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL, 33612

Abstract

Previous studies of the structure-coronary vasoactivity relationships of adenosines substituted at N-6 identified certain simple alkyl and aralkyl groups that can promote activity and others that reduce activity. The present study shows that such alkyl and aryl moieties, when combined in an N-6 substituent, can contribute additively to coronary vasoactivity.

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Coronary Vasoactivity of Novel N⁶-Substituted Adenosines

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Coronary Vasoactivity of Novel N6-Substituted Adenosines

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Coronary Vasoactivity of Novel N⁶-Substituted Adenosines