Effect of Endogenous Phospholipids on the [³H]R-Pia Binding to A₁ Adenosine Receptors from PIG Cerebral Cortex

V. Casadó Department de Bioquimica i Fisiologia. Facultat de Quimica, Universitat de Barcelona, Marti i Franques 1, 08071, Barcelona. Catalunya, Spain

J. Mallol Department de Bioquimica i Fisiologia. Facultat de Quimica, Universitat de Barcelona, Marti i Franques 1, 08071, Barcelona. Catalunya, Spain

C. Lluis E. I. Canela Department de Bioquimica i Fisiologia. Facultat de Quimica, Universitat de Barcelona, Marti i Franques 1, 08071, Barcelona. Catalunya, Spain

R. Franco Department de Bioquimica i Fisiologia. Facultat de Quimica, Universitat de Barcelona, Marti i Franques 1, 08071, Barcelona. Catalunya, Spain

Abstract

The effect of phospholipases on the membrane-bound and solubilized A₁ adenosine receptor has been studied. The results indicate that phospholipids are essential for the functionality of the A₁ adenosine receptor and that there is a co-solubilization of receptor and phospholipids.

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Effect of Endogenous Phospholipids on the [³H]R-Pia Binding to A₁ Adenosine Receptors from PIG Cerebral Cortex

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Effect of Endogenous Phospholipids on the [3H]R-Pia Binding to A1 Adenosine Receptors from PIG Cerebral Cortex

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Effect of Endogenous Phospholipids on the [³H]R-Pia Binding to A₁ Adenosine Receptors from PIG Cerebral Cortex