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Nucleosides and Nucleotides Volume 10, 1991 - Issue 5
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Characteristics of Adenosine-Mediated Inhibition of Tachykinin Release from Perifused Myenteric Plexus Synaptosomes

M. A. Cook Department of Pharmacology and Toxicology, University of Western Ontario, London Ontario, Canada, N6A 5C1
&
R. M. Broad Department of Pharmacology and Toxicology, University of Western Ontario, London Ontario, Canada, N6A 5C1
Pages 1183-1184 | Published online: 04 Oct 2006
 
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Abstract

Adenosine receptor agonists were shown to inhibit evoked release of the tachykinins Substance P and Neurokinin-A from perifused myenteric synaptosomes. The potencies of selective A1 and A2 agonists are consistent with activity at adenosine A1 receptors located on the nerve endings.

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