Calcium Antagonists Modulate ³H-Purine Release from Rat Striatum Glial Cultures Via Vscc-Dependent and Independent Mechanisms

P. Ballerini Institute of Neuroscience, Chair of Pharmacology, University of Chair Medical School, Via dei Vestini 31, Chieti, Italy

R. Cccarelli Institute of Neuroscience, Chair of Pharmacology, University of Chair Medical School, Via dei Vestini 31, Chieti, Italy

P. Di Iorio Institute of Neuroscience, Chair of Pharmacology, University of Chair Medical School, Via dei Vestini 31, Chieti, Italy

H. Di Huzio Institute of Neuroscience, Chair of Pharmacology, University of Chair Medical School, Via dei Vestini 31, Chieti, Italy

S. Ferrari Institute of Neuroscience, Chair of Pharmacology, University of Chair Medical School, Via dei Vestini 31, Chieti, Italy

F. Caciagli Institute of Neuroscience, Chair of Pharmacology, University of Chair Medical School, Via dei Vestini 31, Chieti, Italy

Abstract

Electrical stimulation increased both ³H-purine release and ⁴⁵Ca²⁺ influx in rat primary cultures of astrocytes. Nitrendipine and w-conotoxin reduced the first event being the ion fluxes unaffected. Only when the outward K⁺-currents were impared, 90nM nitrendipine decreased the electrical evoked glial cell inward ⁴⁵Ca²⁺ fluxes too.

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Calcium Antagonists Modulate ³H-Purine Release from Rat Striatum Glial Cultures Via Vscc-Dependent and Independent Mechanisms

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Calcium Antagonists Modulate 3H-Purine Release from Rat Striatum Glial Cultures Via Vscc-Dependent and Independent Mechanisms

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Calcium Antagonists Modulate ³H-Purine Release from Rat Striatum Glial Cultures Via Vscc-Dependent and Independent Mechanisms