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Nucleosides and Nucleotides Volume 10, 1991 - Issue 5
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Mapping the Xanthine CS-Region of the Adenosine A, Receptor with Computer Graphics

E. M. van der Wenden Center for Bio-Pharmaceutical Sciences, Div. of Medicinal Chemistry, P.O. Box 9502, 2300, RA Leiden, The Netherlands
,
P. J.M. van Galen Center for Bio-Pharmaceutical Sciences, Div. of Medicinal Chemistry, P.O. Box 9502, 2300, RA Leiden, The Netherlands
,
A. P. Ijzerman Center for Bio-Pharmaceutical Sciences, Div. of Medicinal Chemistry, P.O. Box 9502, 2300, RA Leiden, The Netherlands
&
W. Soudijn Center for Bio-Pharmaceutical Sciences, Div. of Medicinal Chemistry, P.O. Box 9502, 2300, RA Leiden, The Netherlands
Pages 1199-1200 | Published online: 04 Oct 2006
 
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Abstract

Adenosine A, antagonists cause, among other effects, stimulation of the central nervous system, renal vasodilatation and facilitation of the atrio-ventricular conduction. These possible applications call for an examination of the antagonist properties, in order to develop newer and more selective antagonists.

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