A₁ and A₂ Adenosine Receptors Involvement in Controlling Purine and Acetylcholine Release From Rat Hippocampal Slices

P. Di Iorio Institute of Neuroscience, Chair of Pharmacology, University of Chieti, Via dei Vestini 31, Chieti, Italy

P. Ballerini Institute of Neuroscience, Chair of Pharmacology, University of Chieti, Via dei Vestini 31, Chieti, Italy

R. Ciccarelli Institute of Neuroscience, Chair of Pharmacology, University of Chieti, Via dei Vestini 31, Chieti, Italy

M. Di Muzio Institute of Neuroscience, Chair of Pharmacology, University of Chieti, Via dei Vestini 31, Chieti, Italy

U. Traversa Institute of Pharmacology and Pharmacognosy, Chair of Molecular Pharmacology, University of Trieste, Via A. Valerio 32, Trieste, Italy

F. Caciagli Institute of Neuroscience, Chair of Pharmacology, University of Chieti, Via dei Vestini 31, Chieti, Italy

Abstract

The different role of presynaptic A₁ and A₂ adenosine receptor subtypes on a possible autoregulation of endogenous purine outflow as well as on the ACh release, simultaneously assayed, was evaluated in rat hippocampal slices, at rest and under a field electrical stimulation.

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A₁ and A₂ Adenosine Receptors Involvement in Controlling Purine and Acetylcholine Release From Rat Hippocampal Slices

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A₁ and A₂ Adenosine Receptors Involvement in Controlling Purine and Acetylcholine Release From Rat Hippocampal Slices