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Nucleosides and Nucleotides Volume 11, 1992 - Issue 7
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Original Articles

Synthesis of Suitably-Protected Phosphoramidites of 2′-Fluoro-2′-Deoxyguanosine and 2′-Amino-2′-Deoxyguanosine for Incorporation Into Oligoribonucleotides

Fritz Benseler Max-Planck-Institut fur experimentelle Medizin, Abteilung Chemie, Hermann-Rein-Strasse 3, W-3400, Gottingen, FRG
,
David M. Williams Max-Planck-Institut fur experimentelle Medizin, Abteilung Chemie, Hermann-Rein-Strasse 3, W-3400, Gottingen, FRG; Cruachem, Todd Campus, West of Scotland Science Park, Glasgow, UK
&
Fritz Eckstein Max-Planck-Institut fur experimentelle Medizin, Abteilung Chemie, Hermann-Rein-Strasse 3, W-3400, Gottingen, FRG
Pages 1333-1351 | Received 27 Nov 1991, Accepted 19 Mar 1992, Published online: 23 Sep 2006
 
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Abstract

A novel synthesis of 2′-fluoro-2′-deoxyguanosine employing DAST as the fluorinating agent is presented. The preparation of its phosphoramidite as well as that of 2′-amino-2′-deoxyguanosine is also described.

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