Synthesis of 2′,3′-Dideoxy-3′-C-Hydroxymethyl Nucleosides Having the L-Configuration as Potential Inhibitors of HIV

Ingemar Kvarnström Department of Chemistry, Linköping University, S-581 83, Linköping, Sweden

Lars Svansson Department of Chemistry, Linköping University, S-581 83, Linköping, Sweden

Carina Svensson Department of Chemistry, Linköping University, S-581 83, Linköping, Sweden

Stefan Department of Chemistry, Linköping University, S-581 83, Linköping, Sweden

C. T. Svensson Department of Chemistry, Linköping University, S-581 83, Linköping, Sweden

Björn Classon Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden

Bertil Samuelsson Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden; Astra Hässle AB, S-431 83, Mölndal, Sweden

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Abstract

Synthesis of 2′,3′-Dideoxy-3′-C-(hydroxymethyl)-α- and β-L-erythro-pentofuranosyl nucleosides of thymine, cytosine and adenine is reported.

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Synthesis of 2′,3′-Dideoxy-3′-C-Hydroxymethyl Nucleosides Having the L-Configuration as Potential Inhibitors of HIV

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Synthesis of 2′,3′-Dideoxy-3′-C-Hydroxymethyl Nucleosides Having the L-Configuration as Potential Inhibitors of HIV

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