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Abstract
A new cyclic AMP analogue, adenosine- 3′, 5′-cyclic methyl phosphonate (cAMP-Me) was chemically synthesized. This compound was not a substrate for phosphodiesterase, and it did not activate cAMP-dependent protein kinases (type I or type II). However, it inhibited cAMP phosphodiesterase and protein kinase at milimolar concentration levels. It also inhibited malignant cell proliferation in vitro.