Synthetic Nucleosides and Nucleotides. XXX.¹ Synthesis and Antiviral Activity of 3′-Azido, 2′,3′-Unsaturated and 2′,3′-Dideoxy Derivatives of E-5-Styryl-2′-Deoxyuridine on Human Immunodeficiency Virus

Abstract

Some new 3′-azido, 2′,3′-unsaturated and 2′,3′-dideoxy 5-styryl analogs of deoxyuridine-related compounds have been synthesized and evaluated against human immunodeficiency virus in vitro. Among these compounds, 3′-azido-2′,3′-dideoxy-5-E-styryluridine (6) and 2′,3′-dideoxy-E-5-styryluridine (9) were found to be active, with ED₅₀ values of 5 and 10 μg/ml respectively.