Synthesis of Some Analogues Of 1-[(2-Hydroxyethoxy)-methyl]-6-(phenylthio) Thymine (HEPT) which have Different types of Acyclic Structures

Hiromichi Tanaka School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo, 142, Japan

Tadashi Miyasaka School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo, 142, Japan

Kouichi Sekiya Mitsubishi Kasei Corporation Research Center, Yokohama, 227, Japan

Hideaki Takashima Mitsubishi Kasei Corporation Research Center, Yokohama, 227, Japan

Masaru Ubasawa Mitsubishi Kasei Corporation Research Center, Yokohama, 227, Japan

Issei Nitta Mitsubishi Kasei Corporation Research Center, Yokohama, 227, Japan

Masanori Baba Fukushima Medical College, Fukushima, 960-12, Japan

R. T. Walker Department of Chemistry, University of Birmingham, Birmingham, B15 2TT, United Kingdom

E. De Clercq Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000, Leuven, Belgium

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Abstract

Analogues of a recently developed specific anti-HIV-1 agent HEPT, 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine, having different types of acyclic moieties were synthesized based on lithiation chemistry. Anti-HIV-1 activity of these analogues is also described.

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Synthesis of Some Analogues Of 1-[(2-Hydroxyethoxy)-methyl]-6-(phenylthio) Thymine (HEPT) which have Different types of Acyclic Structures

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Synthesis of Some Analogues Of 1-[(2-Hydroxyethoxy)-methyl]-6-(phenylthio) Thymine (HEPT) which have Different types of Acyclic Structures

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