Chiral Phosphoromorpholidate Derivatives of Oligothymidylate and Their Hybridization Abilities

Masanori Kitamura Division of Molecular Engineering, Graduate School of Engineering, Kyoto University, Sakyo-ku, Kyoto, 606

Hiroaki Ozaki Division of Molecular Engineering, Graduate School of Engineering, Kyoto University, Sakyo-ku, Kyoto, 606

Kazushige Yamana Department of Applied Chemistry, Faculty of Engineering, Himeji Institute of Technology, 2167 Shosha, Himeji, 671-22, Japan

Takeo Shimidzu Division of Molecular Engineering, Graduate School of Engineering, Kyoto University, Sakyo-ku, Kyoto, 606

Abstract

Interactions of diastereomerically pure phosphoromorpholidate analogs of oligothymidylate with poly(dA) were examined. Obvious differences between diastereomers appeared in duplex formation and tentative stereochemical characterizations of them were done.

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Chiral Phosphoromorpholidate Derivatives of Oligothymidylate and Their Hybridization Abilities

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Chiral Phosphoromorpholidate Derivatives of Oligothymidylate and Their Hybridization Abilities

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