Partial Protection of Carbohydrate Derivatives. Part 27.¹ Further Improvement in the Protecting Procedure for Oligonucleotide Synthesis in Terms of a Cellulose Acetate Derivative as a Polymer-Support

Kazuo Kamaike Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Tokyo College of Pharmacy Horinouchi, Hachioji, Tokyo, Japan, 192-03

Tomohiro Ogawa Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Tokyo College of Pharmacy Horinouchi, Hachioji, Tokyo, Japan, 192-03

Yasushi Inoue Department of Chemistry, Faculty of Science, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo, Japan, 152

Yoshiharu Ishido Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Tokyo College of Pharmacy Horinouchi, Hachioji, Tokyo, Japan, 192-03

Abstract

Utilization of a (3-carboxy)propionyl spacer for the cellulose acetate polymer-support, a comparative study of 2-cyanoethyl and diphenylcarbamoyl protecting groups for the O ⁶-position of the guanosine unit, protecting groups for 1-β-D-ribofur-anosylthymine (rT) and pseudouridine (Ψ) is described in connection with the syntheses of oligoribonucleotides, i.e., a tridecamer, ApAp-GpGpApApApApUpUpApUpG, and a dodecamer, UpCpCpGpGprTp-ΨpGpApUpU.

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Partial Protection of Carbohydrate Derivatives. Part 27.¹ Further Improvement in the Protecting Procedure for Oligonucleotide Synthesis in Terms of a Cellulose Acetate Derivative as a Polymer-Support

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Partial Protection of Carbohydrate Derivatives. Part 27.1 Further Improvement in the Protecting Procedure for Oligonucleotide Synthesis in Terms of a Cellulose Acetate Derivative as a Polymer-Support

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Partial Protection of Carbohydrate Derivatives. Part 27.¹ Further Improvement in the Protecting Procedure for Oligonucleotide Synthesis in Terms of a Cellulose Acetate Derivative as a Polymer-Support