Synthesis of Adenosine, Guanosine and Cytidine Monomer Building Units Bearing the [[2-(Methylthio)-phenyl]thio]methyl (MPTM) Group as The 2′-Hydroxyl Protecting Group

Abstract

A new 2′-hydroxyl protecting group, [[2-(methylthio)phenyl]thio]methyl (MPTM), was introduced into the 2′-position of adenosine, guanosine and cytidine building units required for the synthesis of oligoribonucleotides.