Use of a Base-Labile Protected Derivative of 6-Mercaptohexanol for the Preparation of Oligonucleotides Containing a Thiol Group at the 5′-End

Beatriz G. de la Torre Dpt of Molecular Genetics, CID-CSIC, Jordi Girona 18–26., 08034, Barcelona, Spain

Anna Maria Aviñó Dpt of Molecular Genetics, CID-CSIC, Jordi Girona 18–26., 08034, Barcelona, Spain

Mónica Escarceller Dpt of Molecular Genetics, CID-CSIC, Jordi Girona 18–26., 08034, Barcelona, Spain

Miriam Royo Dpt of Organic Chemistry, University of Barcelona, 08028, Barcelona, Spain

Fernando Albericio Dpt of Organic Chemistry, University of Barcelona, 08028, Barcelona, Spain

Ramon Eritja Dpt of Molecular Genetics, CID-CSIC, Jordi Girona 18–26., 08034, Barcelona, Spain

Abstract

The preparation of a base-labile (Dnpe) protected derivative of 6-mercaptohexanol is described. The use of the phosphoramidite derivative of this compound improves both yields and the time needed for the preparation of oligonucleotides containing a thiol group at the 5′-end.

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Use of a Base-Labile Protected Derivative of 6-Mercaptohexanol for the Preparation of Oligonucleotides Containing a Thiol Group at the 5′-End

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Use of a Base-Labile Protected Derivative of 6-Mercaptohexanol for the Preparation of Oligonucleotides Containing a Thiol Group at the 5′-End

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