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Original Articles

New Non-Aromatic Triazinic Nucleosides: Synthesis and Antiretroviral Evaluation of β-Ribosylamine Nucleoside Analogs

, , , , , & show all
Pages 995-1008 | Received 12 Jun 1995, Accepted 18 Dec 1995, Published online: 15 Aug 2006
 

Abstract

Various 5-alkyl-6-aza-5,6-dihydrouridines and 6-(β-D-ribopyranosyl)-5-alkyl-6-aza-5,6-dihydrouracils have been synthesized. A new regioselective method is described for coupling triazinic bases to the sugar unit. Different epimers were isolated. Antiretroviral activity against Visna virus was evaluated.

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