The Effects of 2-5A on Protein Synthesis in Wheat Germ Extracts and Tobacco Protoplasts

Erkki Truve Institute of Chemical Physics and Biophysics, Akadeemia tee 23, EE0026, Tallinn, Estonia

Lenne Nigul Institute of Chemical Physics and Biophysics, Akadeemia tee 23, EE0026, Tallinn, Estonia

Teemu H. Teeri Institute of Biotechnology, P. O. Box 56, Viikinkaari 9, FIN-00014 University of Helsinki, Finland

Merike Kelve Institute of Chemical Physics and Biophysics, Akadeemia tee 23, EE0026, Tallinn, Estonia

Abstract

Nonphosphorylated 2-5A inhibited translation and caused RNA degradation in wheat germ extract, whereas 3-5A had no effect. Protein synthesis inhibition by 2-5A was observed in tobacco protoplasts. 70 kD 2-5A-binding protein was found in potato leaf extracts by chemical crosslinking.

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The Effects of 2-5A on Protein Synthesis in Wheat Germ Extracts and Tobacco Protoplasts

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The Effects of 2-5A on Protein Synthesis in Wheat Germ Extracts and Tobacco Protoplasts

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