An Improved Synthesis of Azidothymidine

M. I. Balagopala Department of Chemistry, Florida A &M University, Tallahassee, FL, 32307.

A. P. Ollapally Department of Chemistry, Florida A &M University, Tallahassee, FL, 32307.

H. J. Lee College of Pharmacy and Pharmaceutical Sciences, Florida A &M University, Tallahassee, FL, 32307

Abstract

A convenient and high yielding procedure is described for a direct conversion of thymidine (1) into 2,3′-anhydrothymidine (2) using the Mitsunobu reaction. Isolation and characterization of two new compounds, 3 and 4, are discussed. AZT has been synthesized from 1 in two steps, in 62% overall yield, by heating 2 with NaN₃ in DMF.

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An Improved Synthesis of Azidothymidine

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An Improved Synthesis of Azidothymidine

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