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A series of 2′-deoxy, 2′,3′-unsaturdted and 2′,3′-dideoxynucleoside analogues, which have an additional methyl group at the 4′-position, have been synthesized. When evaluated for their inhibitory activity against HIV in MT-4 cell, 2′-deoxy-4′-C-methyl nucleosides exhibited potent activity.
†This paper is dedicated to Dr. Yoshihisa Mizuno on the occasion of his 75th birthday.
†This paper is dedicated to Dr. Yoshihisa Mizuno on the occasion of his 75th birthday.
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