The 1,1-Dianisyl-2,2,2-trichloroethyl Moiety as a New Protective Group for the Synthesis of Dinucleostde Trifluoromethylphosphonates

Rosa Maria Karl Institut für Physiologische Chemie, Technische Universitat München, Biedersteinerstraße 29, D-80802, München, Germany

Wolfgang Richter Institut für Physiologische Chemie, Technische Universitat München, Biedersteinerstraße 29, D-80802, München, Germany

Roland Klösel Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstraße 4, D-85747, Garching, Germany

Michael Mayer Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstraße 4, D-85747, Garching, Germany

Ivar Ugi* Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstraße 4, D-85747, Garching, Germany

Abstract

The new 1,1-Dianisyl-2,2,2-trichloroethyl moiety (DATE) is used as an acid and base stable protective group for nucleosides. 5′-O-DATE-thymidine and 3′-O-acetyl-thymidine are phosphorylated with CF₃P(NR₂)₂ to the corresponding thymidine trifluoromethylphosphonous amidites. These building blocks are coupled with appropriate protected thymidines to a dinucleotide trifluoromethylphosphonate.

*Dedicated to Dr. Yoshihisa Mizuno on the occasion of his 75th birthday

Notes

*Dedicated to Dr. Yoshihisa Mizuno on the occasion of his 75th birthday

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

The 1,1-Dianisyl-2,2,2-trichloroethyl Moiety as a New Protective Group for the Synthesis of Dinucleostde Trifluoromethylphosphonates

Information for

Open access

Opportunities

Help and information

The 1,1-Dianisyl-2,2,2-trichloroethyl Moiety as a New Protective Group for the Synthesis of Dinucleostde Trifluoromethylphosphonates

Abstract

Notes

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature