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Abstract
We have investigated the thermodynamic stability of DNA and RNA G-quartet by circular dichroism spectroscopy, gel electrophoresis, and melting analysis. The free energy (δG°37) for G-quartet formation of d(TTGGGG)4 and r(UUGGGG)4 at 100 mM NaCl and 37°C were 1.4 kcal mol-1 and −3.0 kcal mol-1, respectively. On the other hand, at 100 mh4 KCI, δG°37 of the DNA and RNA were −10.0 kcal mol-1 and −8.2 kcal mol-1. This result indicates that the dependence of DNA G-quartet stability on these ions is larger than that of RNA.
†This paper is dedicated to Dr. Yoshihisa Mizuno on the occasion of his 75th birthday.
Notes
†This paper is dedicated to Dr. Yoshihisa Mizuno on the occasion of his 75th birthday.
