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Nucleosides and Nucleotides Volume 15, 1996 - Issue 1-3
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Original Articles

Drug Binding to Higher Ordered DNA Structures: Ethidium Bromide Complexation with Parallel Quadruple-Stranded DNA

Toshio Shida Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, 3-15-1 Tokida, Ueda., Nagano, 386, Japan
,
Norihito Ikeda Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, 3-15-1 Tokida, Ueda., Nagano, 386, Japan
&
Junichi Sekiguchi Department of Applied Biology, Faculty of Textile Science and Technology, Shinshu University, 3-15-1 Tokida, Ueda., Nagano, 386, Japan
Pages 599-605 | Published online: 21 Aug 2006
 
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Abstract

The interaction between ethidium bromide and a parallel G4-DNA, which is a quadruplex composed from four oligonucleotides containing a dG cluster, has been investigated. [d(TTGGGGTT)]4 formed a complex with ethidium bromide, which was assumed to be intercalated between the adjacent guanine tetrads of the quadruplex.

#This paper is dedicated to Prof. Yoshihisa Mizuno on the occasion of his 75th birthday.

Notes

#This paper is dedicated to Prof. Yoshihisa Mizuno on the occasion of his 75th birthday.

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Related Research Data

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