Oligonucleotide Labeling Methods 4. Direct Labeling Reagents with a Novel, Non-Nucleosidic, Chirally Defined 2-Deoxy-β-D-Ribosyl Backbone.

Thomas H. Smith Nucleic Acids Chemistry Division, CLONTECH Laboratories, Inc., 1020, East Meadow Circle, Palo Alto, CA, 94303, USA

Mark A. Kent Nucleic Acids Chemistry Division, CLONTECH Laboratories, Inc., 1020, East Meadow Circle, Palo Alto, CA, 94303, USA

Sylvester Muthini Nucleic Acids Chemistry Division, CLONTECH Laboratories, Inc., 1020, East Meadow Circle, Palo Alto, CA, 94303, USA

Steven J. Boone Nucleic Acids Chemistry Division, CLONTECH Laboratories, Inc., 1020, East Meadow Circle, Palo Alto, CA, 94303, USA

Paul S. Nelson Nucleic Acids Chemistry Division, CLONTECH Laboratories, Inc., 1020, East Meadow Circle, Palo Alto, CA, 94303, USA

Abstract

Novel solid supports and CE-phosphoramidite reagents have been prepared featuring a unique 2′-deoxyribosyl backbone. These chirally pure reagents form the basis of an oligonucleotide labeling system which provides diastereomerically pure oligonucleotides.

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Oligonucleotide Labeling Methods 4. Direct Labeling Reagents with a Novel, Non-Nucleosidic, Chirally Defined 2-Deoxy-β-D-Ribosyl Backbone.

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Oligonucleotide Labeling Methods 4. Direct Labeling Reagents with a Novel, Non-Nucleosidic, Chirally Defined 2-Deoxy-β-D-Ribosyl Backbone.

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