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Nucleosides and Nucleotides Volume 16, 1997 - Issue 10-11
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Original Articles

Incorporation of 5′-N-BOC-2′, 5′-Dideoxynucleoside-3′-O-Phosphoramidites Into Oligonucleotides by Automated Synthesis

Kenneth D. James Department of Chemistry, Indiana University, Bloomington, IN
,
Guenter von Kiedrowski Lehrstuhl fuer Organische Chemie I-Bioorganische Chemie -Ruhr-Universitaet Bochum Bochum, Germany
&
Andrew D. Ellington Department of Chemistry, Indiana University, Bloomington, IN
Pages 1821-1836 | Received 27 Nov 1996, Accepted 15 Apr 1997, Published online: 20 Aug 2006
 
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Abstract

An efficient method for synthesizing 5′-Boc-5′-amino-2′, 5′- dideoxynucleoside phosphoramidites and conditions for their incorporation in solid-phase oligonucleotide synthesis are presented.

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