Enzymatic Synthesis of 2′,5′-Dideoxv Purine Nucleosides and Related Compounds

Reza Fathi PharmaGenics, Inc., 4 Pearl Court, Allendale, New Jersey, 07401, USA

Kenneth J. Nawoschik PharmaGenics, Inc., 4 Pearl Court, Allendale, New Jersey, 07401, USA

Melissa Zavoda PharmaGenics, Inc., 4 Pearl Court, Allendale, New Jersey, 07401, USA

Alan F. Cook PharmaGenics, Inc., 4 Pearl Court, Allendale, New Jersey, 07401, USA

Abstract

A wide range of 2′,5′-dideoxy-nucleosides, including 6- substituted purine, pyrazolo[3,4-d]pyrimidine and 1-deazapurine derivatives, has been enzymatically prepared using purine nucleoside phosphorylase. Specificity towards cleavage by bacterial versus mammalian purine nucleoside phosphorylase was evaluated.

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Enzymatic Synthesis of 2′,5′-Dideoxv Purine Nucleosides and Related Compounds

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Enzymatic Synthesis of 2′,5′-Dideoxv Purine Nucleosides and Related Compounds

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