Synthesis of Unsaturated Analogues of 9-[2(Phosphono- Methoxy)Propyl]Guanine as Antiviral Agents

Palmarisa Franchetti Dipartimento di Scienze Chimiche, Università di Camerino, 62032, Camerino, Italy

Ghassan Abu Sheikha Dipartimento di Scienze Chimiche, Università di Camerino, 62032, Camerino, Italy

Paolo Perlini Dipartimento di Scienze Chimiche, Università di Camerino, 62032, Camerino, Italy

Farhat Farhat Dipartimento di Scienze Chimiche, Università di Camerino, 62032, Camerino, Italy

Mario Grifantini Dipartimento di Scienze Chimiche, Università di Camerino, 62032, Camerino, Italy

Graziella Perra Dipartimento di Biologia Sperimentale, Università di Cagliari, 09124, Cagliari, Italy

Carlo Milia Dipartimento di Biologia Sperimentale, Università di Cagliari, 09124, Cagliari, Italy

Monica Putzolu Dipartimento di Biologia Sperimentale, Università di Cagliari, 09124, Cagliari, Italy

Paolo La Colla Dipartimento di Biologia Sperimentale, Università di Cagliari, 09124, Cagliari, Italy

Maria Elena Marongiu Dipartimento di Biologia Sperimentale, Università di Cagliari, 09124, Cagliari, Italy

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Abstract

The synthesis of 9-[2-(phosphonomethoxy)allyl]guanine (1) and 9-[2-(phosphonomethoxy)allyl]-8-aza-guanine (2), two new unsaturated acyclic phosphonate nucleosides analogues of the anti-HIV agents PMPG and 8-aza-PMPG, is described. Compounds 1 and 2 were evaluated for activity against human immunodeficiency virus (HIV-1 and HIV-2) and herpes simplex virus (HSV-1 and HSV-2).

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Synthesis of Unsaturated Analogues of 9-[2(Phosphono- Methoxy)Propyl]Guanine as Antiviral Agents

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Synthesis of Unsaturated Analogues of 9-[2(Phosphono- Methoxy)Propyl]Guanine as Antiviral Agents

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