A Fluorescence Detection and Selection Device for Dna-Molecules Bound to Microspheres

Johan Holm Karolinska Institute, Dep. of Medical Biophysics, S-171 77, Stockholm, Sweden; Industrial Microelectronic Center (IMC) AB, P.O. Box 1084, Kista, S-164 21, Sweden

Håkan Elderstig Industrial Microelectronic Center (IMC) AB, P.O. Box 1084, Kista, S-164 21, Sweden

Ove Kristensen Karolinska Institute, Dep. of Medical Biophysics, S-171 77, Stockholm, Sweden

Rudolf Rigler Karolinska Institute, Dep. of Medical Biophysics, S-171 77, Stockholm, Sweden

Abstract

A device for the detection and selection of DNA-molecules bound to microspheres has been realized. It is based on a quartz chip with a capillary flowsystem, and confocal fluorescence detection of DNA. The device is to be used to identify and isolate single DNA-molecules for sequencing experiments.

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A Fluorescence Detection and Selection Device for Dna-Molecules Bound to Microspheres

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A Fluorescence Detection and Selection Device for Dna-Molecules Bound to Microspheres

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