Antiviral Activity of Antisense Oligonucleotides Against Various Targets of Herpes Simplex Virus 1 (Hsv1) and Coxsackievirus B3 (Cvb3) Genome

E. Birch-Hirschfeld Institute of Virology at the Medical Center of the Friedrich Schiller University Jena, Winzerlaer Str. 10, 07745, Jena, Germany

C. M. Knorre Institute of Virology at the Medical Center of the Friedrich Schiller University Jena, Winzerlaer Str. 10, 07745, Jena, Germany

A. Stelzner Institute of Virology at the Medical Center of the Friedrich Schiller University Jena, Winzerlaer Str. 10, 07745, Jena, Germany

M. Schmidtke Institute of Virology at the Medical Center of the Friedrich Schiller University Jena, Winzerlaer Str. 10, 07745, Jena, Germany

Abstract

The influence of chemical modification on the antiviral activity of oligonucleotides was studied on Green monkey kidney cells (GMK) using a known antisense oligodeoxynucleotide (AS-ODN) directed against the IE-110 gene of HSVl. The highest antiviral activity was observed with ODNs carrying exclusively phosphothioate internucleotide linkages. CVB3-specific ODNs of this type were synthesized and successfully tested for antiviral activity on HeLa cells.

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Antiviral Activity of Antisense Oligonucleotides Against Various Targets of Herpes Simplex Virus 1 (Hsv1) and Coxsackievirus B3 (Cvb3) Genome

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Antiviral Activity of Antisense Oligonucleotides Against Various Targets of Herpes Simplex Virus 1 (Hsv1) and Coxsackievirus B3 (Cvb3) Genome

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