Oligonucleotides With Purine Nitrogen-7 as Glycosylation Site

Frank Seela Universität Osnabrück Barbarastrasse 7, Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, D-49069, Osnabrück, Germany

Peter Leonard Universität Osnabrück Barbarastrasse 7, Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, D-49069, Osnabrück, Germany

Abstract

The synthesis of phosphoramidites (2 and 3) derived from hypoxanthine and isoguanine N⁷-2¹-deoxyribonucleosides is described. Solid-phase synthesis furnishes oligonucleotides containing N⁷-glycosylated purines. New base pairs between purine N⁷- and N9-nucleosides are proposed.

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Oligonucleotides With Purine Nitrogen-7 as Glycosylation Site

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Oligonucleotides With Purine Nitrogen-7 as Glycosylation Site

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