Synthesis and Biological Activity of New Sugar Modified 2′,5′-Oligoadenylate Trimers

Evgeny I. Kvasyuk -Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, 220141, Belarus

Tamara I. Kulak -Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, 220141, Belarus

Olga V. Tkachenko -Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, 220141, Belarus

Svetlana L. Sentyureva -Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, 220141, Belarus

Igor A. Mikhailopulo -Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, 220141, Belarus

Robert J. Suhadolnik -Department of Biochemistry, -Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, 220141, Belarus

Earl E. Henderson -Department of Microbiology and Immunology, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 19140, USA

Susan E. Horvath -Department of Biochemistry, -Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, 220141, Belarus

Ming Xu Gun -Department of Microbiology and Immunology, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, 19140, USA

Wolfgang Pfleiderer -Fakultät für Chemie, Universität Konstanz, Postfach 5560, D-78434, Konstanz

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Abstract

New 2′,5′-oligonucleotide trimers containing 2′,3′-dideoxy-3′-fluoro derivatives of adenosine at the 2′-terminal end of oligomers have been synthesized. Some of the synthesized trimers showed biological inhibitions of HIV-1 reverse transcriptase and HIV-1 induced syncytia formation.

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Synthesis and Biological Activity of New Sugar Modified 2′,5′-Oligoadenylate Trimers

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Synthesis and Biological Activity of New Sugar Modified 2′,5′-Oligoadenylate Trimers

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