Synthesis of 8-(2-Deoxy-β-D-Ribofuranosyl)-Isoxanthopterins New Fluorescent Analogs of 2′-Deoxyguanosine

Abstract

We have synthesized isoxanthopterin and 6-phenylisoxanthopterin nucleosides in form of their 5′-O-dimethoxytritylated 3′-phosphoramidites to be used as fluorescence markers directly in the synthesis of oligonucleotides by a machine-aided solid-support approach. The preparation of the monomers and some results of the oligonucleotide synthesis will be described.