Synthesis and Antiviral Activity of Apio Dideoxy Nucleosides with Azido or Amino Substituent

Abstract

Novel apio dideoxynucleosides with azido or amino substituent were synthesized starting from 1,3-dihydroxyacetone utilizing an acid-catalyzed 1,4-conjugated addition as a key step and evaluated for antiviral activity. Unfortunately, they were found to be neither active against HTV-1, HSV-1,2 and poliovirus nor toxic.