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Nucleosides and Nucleotides Volume 17, 1998 - Issue 12
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Original Articles

Synthesis and Anti-HSV-1 Activity of 6 Substituted Pyrazolo[3,4-d]Pyridazin-7-one Nucleosides

P. G. Baraldi Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, 44100, Italy
,
S. Manfredini Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, 44100, Italy
,
R. Romagnoli Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, 44100, Italy
,
L. Stevanato Dipartimento di Medicina Sperimentale e Diagnostica-Sezione Microbiologia, Università di Ferrara, Ferrara, 44100, Italy
,
A. N. Zaid Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, 44100, Italy
&
R. Manservigi Dipartimento di Medicina Sperimentale e Diagnostica-Sezione Microbiologia, Università di Ferrara, Ferrara, 44100, Italy
Pages 2165-2173 | Received 27 Jan 1998, Accepted 30 Mar 1998, Published online: 16 Aug 2006
 
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Abstract

a new series of 6-substituted N1- and N2 -β-D-ribofuranosyl-pyrazolo[3,4-d]pyridazin-7(6H)-one derivatives (8a-g, 9b-d and 9f-g) has been prepared in the aim to explore the structure-activity relationships and improve the antiviral activity of a series of N1-and N2 -β-D-ribofuranosyl-pyrazolo[4,3-d]pyrimidin-7(6H)-one derivatives previously reported by us. The studied compounds were preliminary tested for their in vitroa antiviral activity against HSV-1. Among them 8f and 9f were found 2 fold more active than those belonging to the parent series.

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