Abstract
The reaction of 3,5-O-(l,l,3,3-tetraisopropyldisiloxane-l,3-diyl)-2-O-methylribofuranos-1-yl trichloroacetimidate as the ribosyl donor with bis(trimethylsilyl)thymine was studied in detail. As the result, it was concluded that the main product is an α-glycoside derivative unlike the previous report. In connection with this glycosylation, several chemical properties of the byproduct obtained by the Chapman arrangement are described.