Stability Studies in Biological Media of Dimer Phosphotriesters Bearing Glucuronic Acid Residue

Abstract

Hydrolytic stability of dithymidine phosphorothioates and dithioates bearing a glucuronic acid derivative protecting group on the phosphate linkage were studied in various biological media. We found that the enzymatic hydrolysis was accompanied by another reaction resulting in formation of the dithymidine phosphodiesters. We have proposed several possible mechanisms of hydrolysis.