Disaccharide Nucleosides And Their Enzymatic And Chemical Incorporation Into Oligonucleotides

Ekaterina V. Efimtseva Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow, 117984, Russia

Lubov S. Victorova Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow, 117984, Russia

Andrei A. Rodionov Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow, 117984, Russia

Boris S. Ermolinsky Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow, 117984, Russia

Marina V. Fomitcheva Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow, 117984, Russia

Vera L. Tunitskaya Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow, 117984, Russia

Sergey N. Mikhailov Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow, 117984, Russia

Mikko Oivanen Department of Chemistry, University of Turku, FIN-20014, Turku, Finland

Arthur Van Aerschot Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium

Piet Herdewijn Rega Institute, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium

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Abstract

A high yield synthesis of different O-ribofuranosylnucleosides has been achieved. Kinetics of the acid-catalysed hydrolysis of disaccharide nucleosides has been studied. Chemical and enzymatic incorporation of 2′-O-ribofuranosyl-nucleoside residue into oligonucleotides was investigated.

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Disaccharide Nucleosides And Their Enzymatic And Chemical Incorporation Into Oligonucleotides

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