A Versatile Polymer Support Useful for Large-Scale Synthesis of DNA for Biomedical Applications

Abstract

A suitably derivatized MercKogel^R 1 as an efficient solid support for the large-scale synthesis of DNA for biomedical applications, is described. Partial hydrolysis of these polyvinylacetate resins with 0.5 M NaOH solution¹ at room temperature for 30–80 min. yielded carriers 1 that could be loaded with 120, 150, 258, and 368 μmoles of nucleosides g⁻¹.

At present a DAAD fellow in the University of Ulm, Section of Polymers, Germany.

Notes

At present a DAAD fellow in the University of Ulm, Section of Polymers, Germany.