Chemical Synthesis and Properties of Long-Chain Alkoxymethyl-Nucleobase Derivatives

L. Kovalenko institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia Phone: ++371-2559372 Fax: ++371-2559372 E-mail: [email protected]

M. Madre institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia Phone: ++371-2559372 Fax: ++371-2559372 E-mail: [email protected]

S. Lindau Martin Luther University Halle-Wittenberg, Institute of Biochemistry, D-06120, Halle, (Saale), Germany Phone: ++49-345-5524855 Fax: ++49-345-5524855 E-mail: [email protected]

C. Bohley Martin Luther University Halle-Wittenberg, Institute of Biochemistry, D-06120, Halle, (Saale), Germany Phone: ++49-345-5524855 Fax: ++49-345-5524855 E-mail: [email protected]

N. Panchenko institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia Phone: ++371-2559372 Fax: ++371-2559372 E-mail: [email protected]

W.-V. Meister Martin Luther University Halle-Wittenberg, Institute of Biochemistry, D-06120, Halle, (Saale), Germany Phone: ++49-345-5524855 Fax: ++49-345-5524855 E-mail: [email protected]

R. Zhuk institute of Organic Synthesis, Aizkraukles 21, LV-1006, Riga, Latvia Phone: ++371-2559372 Fax: ++371-2559372 E-mail: [email protected]

S. Hoffmann Martin Luther University Halle-Wittenberg, Institute of Biochemistry, D-06120, Halle, (Saale), Germany Phone: ++49-345-5524855 Fax: ++49-345-5524855 E-mail: [email protected]

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Abstract

New nucleobase derivatives were synthesized, containing both octyloxymethyl (LCA8) and octadecyloxymethyl (LCA18) substituents at N¹ position of pyrimidine and N⁹ of purine. These substances were studied with respect to the formation of supramolecular structures, i.a. molecular associates as the result of noncovalent interactions. Special attention has been paid to complex formation. The properties of these molecules were investigated by DSC and polarizing microscopy.

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Chemical Synthesis and Properties of Long-Chain Alkoxymethyl-Nucleobase Derivatives

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Chemical Synthesis and Properties of Long-Chain Alkoxymethyl-Nucleobase Derivatives

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