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Abstract
Two naphtho[2,1-b]pyrans (benzocoumarin 1 and benzochromone 2) were covalently linked to a 7-mer ODN. Purification and hydrophobicity studies of the resulting conjugates 1* and 2* were performed by HPLC. Benzochromone conjugate 2* was more hydrophobic than benzocoumarin conjugate 1*. Preliminary data on thermal stability and interaction with HIV reverse transcriptase showed that 1* is slightly more efficient than 2*. This is probably due to the steric hindrance of the 3-diethylamino group in 2.