Possibilities of Triplex-Formation by 21-Mer Oligodeoxyribonucleotides as Analogs of Tetrahymena Pre-rRNA Fragments

W-V Meister Institute of Biochemistry, D-06120 Halle (Saale), Germany Phone: Tel.: ++ 49 -345 -5524855 Fax: Tel.: ++ 49 -345 -5524855 E-mail: [email protected]

S. I. Kargov Moscow State University, Faculty of Chemistry, 119899, Moscow, Russia

E. Birch-Hirschfeld Friedrich Schiller University, Institute of Virology, D-07745, Jena, Germany

C. Bohley Institute of Biochemistry, D-06120 Halle (Saale), Germany Phone: Tel.: ++ 49 -345 -5524855 Fax: Tel.: ++ 49 -345 -5524855 E-mail: [email protected]

G. Burckhardt Friedrich Schiller University, Department of Molecular Biology, D-07745, Jena, Germany

G. Bischoff Friedrich Schiller University, Department of Molecular Biology, D-07745, Jena, Germany

R. Bischoff Department of Oto-, Rhino-, Laryngology, Face and Neck Surgery, D-06110, Halle (Saale), Germany

U. Gromann Institute of Biochemistry, D-06120 Halle (Saale), Germany Phone: Tel.: ++ 49 -345 -5524855 Fax: Tel.: ++ 49 -345 -5524855 E-mail: [email protected]

S. Hoflfmann Institute of Biochemistry, D-06120 Halle (Saale), Germany Phone: Tel.: ++ 49 -345 -5524855 Fax: Tel.: ++ 49 -345 -5524855 E-mail: [email protected]

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Abstract

A potential DNA triple helix of 21-mer oligodeoxyribonucleotides was synthesized and characterized. The strands were chosen to study the interaction of internal guide and intervening sequences analogs as well as adjacent 3′and 5′exon parts around the splicing site of Tetrahymena pre-rRNA. Further in parallel works a series of different RNA and DNA strands was synthesized and combined yielding a suitable order of stability. Here we want to show an isolated examination of a DNA-strand triple helix with defined sequences containing a central mismatched base arrangement and T-A-T bases at the ends.

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Possibilities of Triplex-Formation by 21-Mer Oligodeoxyribonucleotides as Analogs of Tetrahymena Pre-rRNA Fragments

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Possibilities of Triplex-Formation by 21-Mer Oligodeoxyribonucleotides as Analogs of Tetrahymena Pre-rRNA Fragments

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