Deamination of Cyclaradine by Adenosine Deaminase Under High Pressure#

This paper is dedicated to the memory of the late Professor Tsujiaki Hata.

Abstract

The deamination of cyclaradine corresponding to a carbocyclic analogue of ara-A having anti-HSV activity by adenosine deaminase was examined under various pressure. The deamination of (+)- and (±)-cyclaradine was remarkably facilitated by high pressure, and the rate was increased with increasing of pressure. However, (-)-cyclaradine was not deaminated even under high pressure.

This paper is dedicated to the memory of the late Professor Tsujiaki Hata.

Notes

This paper is dedicated to the memory of the late Professor Tsujiaki Hata.