Synthesis of 8-Substituted Analogs of 3′-Deoxy-3′-fluoroadenosine¹⁾

Abstract

After 2′,5′-di-O-protection of 8-bromoadenosine, the product was converted to the xyloside, which was successively treated with diethylaminosulfur trifluoride (DAST) and acid to afford 8-bromo-3′-deoxy-3′-fluoroadenosine. 8-Mercapto and 8-oxy analogs were obtained from 8-bromo congener.