Biologically Active Oligodeoxyribonucleotides. X. Anti-HIV-1 Activity and Stability of Modified Hexanucleotides Containing Glycerol-Skeleton§

This paper is dedicated to the memory of the late Professor Tsujiaki Hata, a former Professor Emeritus of the Tokyo Institute of Technology.

Abstract

Deoxyribose-moieties of modified hexadeoxyribonucleotide 1, which exhibits anti-HIV-1 activity, were partially replaced with glycerol-moieties. Compound 7 with two glycerylguanines at its 3′-end showed more potent anti-HIV-1 activity and more stability against digestion by nucleases than the parent compound 1.

This paper is dedicated to the memory of the late Professor Tsujiaki Hata, a former Professor Emeritus of the Tokyo Institute of Technology.

Current address: Department of Infection Control and Prevention, the University of Tokyo Hospital, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113, Japan.

Current address: Tokyo Senbai Hospital, 1–4–3 Mita, Minato-ku, Tokyo 108, Japan.

Notes

This paper is dedicated to the memory of the late Professor Tsujiaki Hata, a former Professor Emeritus of the Tokyo Institute of Technology.

Current address: Department of Infection Control and Prevention, the University of Tokyo Hospital, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113, Japan.

Current address: Tokyo Senbai Hospital, 1–4–3 Mita, Minato-ku, Tokyo 108, Japan.