Synthesis of Novel Oligodeoxynucleotide Conjugates Containing the Anionophoric Moiety of Pamamycin†

dedicated to late Professor Tsujiaki Hata

Abstract

A series of oligodeoxynucleotides bearing the alkaline hydrolysis product of pamamycin, an antibiotic from Streptomyces aurantiacus with penetration enhancement potency, were prepared by automated solid-phase synthesis. In order to allow conjugation of the anionophoric moiety to the 3′-terminus of oligodeoxy-nucleotides, an appropriately derivatized CPG support was synthesized.

dedicated to late Professor Tsujiaki Hata

Notes

dedicated to late Professor Tsujiaki Hata