Stereocontrolled Synthesis of Dithymidine Phosphorothioates by Use of a Functionalized 5′- Protecting Group Bearing an Imidazole ResidueFootnote†
This paper is dedicated to the memory of the late Professor Tsujiaki Hata.

Takeshi Wada Department of Life Science, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Midoriku, Yokohama, 226, Japan

Naotake Kobayashi Department of Life Science, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Midoriku, Yokohama, 226, Japan

Toshiya Mori Department of Life Science, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Midoriku, Yokohama, 226, Japan

Mitsuo Sekine Department of Life Science, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Midoriku, Yokohama, 226, Japan

Abstract

Diastereoselective formation of internucleotidic phosphorothioate triester bonds was achieved by use of 3-(imidazol-1-ylmethyl)-4′,4″-dimethoxytrityl (IDTr) as a 5′-hydroxyl protecting group in the phosphotriester approach. After removal of all the protecting groups, stereochemistry of the major product was determined as the Spconfiguration by enzymatic digestion.

This paper is dedicated to the memory of the late Professor Tsujiaki Hata.

Notes

This paper is dedicated to the memory of the late Professor Tsujiaki Hata.

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Stereocontrolled Synthesis of Dithymidine Phosphorothioates by Use of a Functionalized 5′- Protecting Group Bearing an Imidazole ResidueFootnote†
This paper is dedicated to the memory of the late Professor Tsujiaki Hata.

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Stereocontrolled Synthesis of Dithymidine Phosphorothioates by Use of a Functionalized 5′- Protecting Group Bearing an Imidazole ResidueFootnote†This paper is dedicated to the memory of the late Professor Tsujiaki Hata.

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Stereocontrolled Synthesis of Dithymidine Phosphorothioates by Use of a Functionalized 5′- Protecting Group Bearing an Imidazole ResidueFootnote†
This paper is dedicated to the memory of the late Professor Tsujiaki Hata.