Convenient Approaches to the Synthesis of Oligonucleotide Macrocycles Containing Non-nucleotide Linkers#

This paper is dedicated to the memory of Professor Tsujiaki Hata.

Abstract

Two convenient, practical routes to the synthesis of non-nucleotide bridged cyclic oligonucleotides have been developed. The first procedure included circularization of oligonucleotides by template-directed ligation on solid phase, while the second procedure involved preparation of a circular oligomer by non-template chemical ligation of a linear precursor in solution. Using these approaches, a series of single- and double-stranded cyclic oligonucleotides with non-nucleotide bridges has been synthesized.

This paper is dedicated to the memory of Professor Tsujiaki Hata.

Notes

This paper is dedicated to the memory of Professor Tsujiaki Hata.