Stereospecificity of 6′-C-Neplanocin A Analogues as Inhibitors of S-Adenosylhomocysteine Hydrolase Activity and Human Immunodeficiency Virus ReplicationFootnote†
Dedicated to the memory of Dr. T. Hata

D. Daelemans Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000, Leuven, Belgium

Anne‐ Mieke Vandamme Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000, Leuven, Belgium

Satoshi Shuto Faculty of Phamaceutical Sciences, Hokkaido University, Sapporo, Japan

Akira Matsuda Faculty of Phamaceutical Sciences, Hokkaido University, Sapporo, Japan

Erik De Clercq Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000, Leuven, Belgium

Abstract

The R- and S-isomers of 6′-C-neplanocin A analogues, which are all known as inhibitors of S-adenosylhomocysteine (AdoHcy) hydrolase, were studied for their inhibitory effects on Human Immunodeficiency Virus type 1 (HIV-1) replication and HIV-1 Tat-mediated transactivation. The R-isomers showed much greater activity against AdoHcy hydrolase than the S-isomers. The same differential activity was observed against the HIV-1 replication and the Tat transactivation.

Dedicated to the memory of Dr. T. Hata

Notes

Dedicated to the memory of Dr. T. Hata

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Stereospecificity of 6′-C-Neplanocin A Analogues as Inhibitors of S-Adenosylhomocysteine Hydrolase Activity and Human Immunodeficiency Virus ReplicationFootnote†
Dedicated to the memory of Dr. T. Hata

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Stereospecificity of 6′-C-Neplanocin A Analogues as Inhibitors of S-Adenosylhomocysteine Hydrolase Activity and Human Immunodeficiency Virus ReplicationFootnote†Dedicated to the memory of Dr. T. Hata

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Stereospecificity of 6′-C-Neplanocin A Analogues as Inhibitors of S-Adenosylhomocysteine Hydrolase Activity and Human Immunodeficiency Virus ReplicationFootnote†
Dedicated to the memory of Dr. T. Hata